Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats
Kebe Edet Obeten,
Gabriel Udo-Affah,
Ettah Ettah Nkanu,
Wonah Eriaowo Justice
Issue:
Volume 7, Issue 2, December 2021
Pages:
23-28
Received:
2 May 2021
Accepted:
24 June 2021
Published:
13 July 2021
Abstract: The research was directed at assessing the prostatic effect of the extract of Parkia biglobosa on the male Wistar rats. Twenty one (21) experimental rats weighing about 90-120 g and divided into three groups consisting of seven animals were used. The control group was fed with normal rat feed and water, while the experimental groups the low and high groups received (300 mg/kgBw) and (500 mg/kgBw) of the extract daily by oral gavage method for thirty one (31) days. All animals were sacrificed a day after the end of the extract administration by cervical dislocation. The prostate was removed, weighed and fix in 10% buffer formalin. Result showed that following administration of extract of Parkia biglobosa, a significant increase was observed in the test group. Histological observation show that administration of Parkia biglobosa at high dose and long duration could result to cystic changes in the epithelium. Study reveals that these focal areas of cystic changes are prognosis of benign prostatic hyperplasia. Other histological observation shows that administration of aqueous extract of Parkia biglobosa at high dose reveal congestion of blood vessels and functional hyperplasia characterized by increased in-folding of the glandular epithelium resulting in the decrease in glandular diameter. Histochemical observation reveals a weak PAS-positive epithelial nuclei and a weak to negative PAS- positive cytoplasm, studies reveal that this could cause atrophic tubules and reactive hyperplasia.
Abstract: The research was directed at assessing the prostatic effect of the extract of Parkia biglobosa on the male Wistar rats. Twenty one (21) experimental rats weighing about 90-120 g and divided into three groups consisting of seven animals were used. The control group was fed with normal rat feed and water, while the experimental groups the low and hig...
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Evaluation of Some Factors Associated with Mother to Child HIV Transmission in Some States in the North Central Part of Nigeria
Eberemu Nkiru Charity,
Edelduok Ekaette Godwin
Issue:
Volume 7, Issue 2, December 2021
Pages:
29-36
Received:
20 June 2021
Accepted:
1 July 2021
Published:
4 August 2021
Abstract: In developing countries, despite the availability of proven interventions for the Prevention of Mother-to-Child Transmission, HIV in children is still a largely uncontrolled epidemic. Data of infants were collected from infant’s medical record and mother’s history charts from four states in North central part of Nigeria. Socio-demographic data such as age, occupation, place of delivery and mode of delivery and the rate prevalence in different states were also collected. The data were analyzed using chi-squared test with 95% confidence intervals and p-value (0.05). Out of one thousand four hundred and sixteen data collected on mode of child birth, the percentage mother to child transmission on children delivered through vaginal and cesarean surgery were 17.3% and 16.7%, respectively. Children delivered at home had the highest percentage HIV infection at 19.7%; while children delivered at private hospital had the lowest 16.5%. Younger mothers between the ages of 17-25 had the highest rate of mother to child transmission. Benue and Plateau states had the highest rate of mother to child transmission 21.7% and 20.4%, respectively compared to Nassarawa and Bauchi with infection rate 13.2 and 12.7%, respectively. The data collected in this study demonstrate the factors associated with mother to child transmission of HIV in some states in north central Nigeria.
Abstract: In developing countries, despite the availability of proven interventions for the Prevention of Mother-to-Child Transmission, HIV in children is still a largely uncontrolled epidemic. Data of infants were collected from infant’s medical record and mother’s history charts from four states in North central part of Nigeria. Socio-demographic data such...
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